喹诺酮类药物的光毒性潜力。

Phototoxic potential of quinolones.

作者信息

Cárdenas A M, Vargas F, Fernández E, Hidalgo M E

机构信息

Laboratorio de Fotobiologia y Fotoquimica, Facultad de Medicina, Universidad de Valparaiso, Chile.

出版信息

J Photochem Photobiol B. 1991 Aug;10(3):249-55. doi: 10.1016/1011-1344(91)85006-3.

DOI:10.1016/1011-1344(91)85006-3

PMID:1663996

Abstract

The photohaemolytic potentials of the quinolones oxolinic acid, pipemidic acid, rosoxacin, norfloxacin, ciprofloxacin and M-193324 (synthesis intermediary) were evaluated and compared with the photohaemolysis induced by nalidixic acid. Quinolones with a piperazine group in position 7 (pipemidic acid, norfloxacin and ciprofloxacin) did not induce photohaemolysis. However, oxolinic acid, rosoxacin and M-193324 produced a concentration- and oxygen-dependent photohaemolysis. Ascorbic acid, histidine and thiourea inhibited the photohaemolysis induced by oxolinic acid, rosoxacin and M-193324, suggesting a photodynamic mechanism similar to that found with nalidixic acid. In addition, deuterium oxide increased the photohaemolysis induced by photohaemolytic quinolones, indicating that this process is mediated by singlet oxygen.

摘要

对恶喹酸、吡哌酸、咯索沙星、诺氟沙星、环丙沙星和M - 193324（合成中间体）等喹诺酮类药物的光溶血潜力进行了评估，并与萘啶酸诱导的光溶血进行了比较。7位带有哌嗪基团的喹诺酮类药物（吡哌酸、诺氟沙星和环丙沙星）未诱导光溶血。然而，恶喹酸、咯索沙星和M - 193324产生了浓度和氧依赖性光溶血。抗坏血酸、组氨酸和硫脲抑制了恶喹酸、咯索沙星和M - 193324诱导的光溶血，表明其光动力机制与萘啶酸相似。此外，重水增加了光溶血喹诺酮类药物诱导的光溶血，表明该过程由单线态氧介导。