Larsen E, Stewart G L, Niederkorn J Y
Department of Biology, University of Texas, Arlington 76019.
Parasitology. 1991 Dec;103 Pt 3:465-70. doi: 10.1017/s0031182000059989.
Infectivity of Trichinella pseudospiralis in Chinese hamsters was greater than that of Trichinella spiralis. Concurrent infection with these two species of parasite was accompanied by an increase in infectivity of T. spiralis. The infectivity of T. pseudospiralis, but not that of T. spiralis, was significantly influenced by host age. Regardless of host age, T. pseudospiralis was more infective for the Chinese hamster than was T. spiralis. Early during infection, enteritis (myeloperoxidase activity) in hamsters infected with T. pseudospiralis alone was significantly less than that seen in animals infected with T. spiralis alone or with both species concurrently. Myositis in hamsters infected with T. pseudospiralis alone was significantly less on days 14, 17 and 25 post-infection (p.i.) than that observed in concurrently infected or T. spiralis-infected animals. On days 11 and 14 p.i. inflammation in diaphragm muscle from concurrently infected hamsters was significantly less than that seen in animals infected with T. spiralis alone. Muscle histology supported these chemical data on myositis. Suppression of the host inflammatory response against early muscle-stage larvae of T. pseudospiralis underlies the greater infectivity of this parasite for the Chinese hamster.
旋毛虫在中国仓鼠中的感染性高于旋毛形线虫。这两种寄生虫同时感染时，旋毛形线虫的感染性会增加。伪旋毛虫的感染性受宿主年龄的显著影响，而旋毛形线虫则不受影响。无论宿主年龄如何，伪旋毛虫对中国仓鼠的感染性都高于旋毛形线虫。在感染早期，单独感染伪旋毛虫的仓鼠的肠炎（髓过氧化物酶活性）明显低于单独感染旋毛形线虫或同时感染这两种线虫的动物。单独感染伪旋毛虫的仓鼠在感染后第14、17和25天的肌炎明显低于同时感染或感染旋毛形线虫的动物。在感染后第11天和第14天，同时感染的仓鼠膈肌的炎症明显低于单独感染旋毛形线虫的动物。肌肉组织学支持了这些关于肌炎的化学数据。宿主对伪旋毛虫早期肌肉期幼虫炎症反应的抑制是这种寄生虫对中国仓鼠感染性更强的基础。
