Barrett B, Brown R, Voland R, Maberry R, Turner R
University of Wisconsin Medical School, 777 S. Mills, Madison, WI 53715, USA.
Eur Respir J. 2006 Aug;28(2):358-63. doi: 10.1183/09031936.06.00002606. Epub 2006 Apr 26.
Due to high incidence and quality-of-life impact, upper respiratory infection substantially impacts on population health. To test or compare treatment effectiveness, a well-designed and validated illness-specific quality-of-life instrument is needed. Data reported in the current study were obtained from a trial testing echinacea for induced rhinovirus infection. Laboratory-assessed biomarkers included interleukin (IL)-8, nasal neutrophil count (polymorphonuclear neutrophils (PMN)), mucus weight, viral titre and seroconversion. The questionnaires used included the general health short form (SF)-8 (24-h recall version), the eight-item Jackson cold scale, and the 44-item Wisconsin Upper Respiratory Symptom Survey (WURSS). In total, 399 participants were inoculated with rhinovirus and monitored over 2,088 person-days. Statistically significant associations were found among nearly all variables. Between-questionnaire correlations were: WURSS-Jackson = 0.81; WURSS-SF-8 = 0.62; and Jackson-SF-8 = 0.60. Correlations with laboratory values were as follows: WURSS-mucus weight = 0.53; Jackson-mucus weight = 0.55; WURSS-viral titre = 0.37; Jackson-viral titre = 0.46; WURSS-IL-8 = 0.31; Jackson-IL-8 = 0.36; WURSS-PMN = 0.31; and Jackson-PMN = 0.28. Neither WURSS nor Jackson yielded satisfactory cut-off scores for diagnosis of infection. Symptomatic and biological outcomes of upper respiratory infection are highly variable, with only modest associations. While Wisconsin Upper Respiratory Symptom Survey and Jackson questionnaires both correlate with biomarkers, neither is a good predictor of induced infection. The inclusion of functional and quality-of-life items in the Wisconsin Upper Respiratory Symptom Survey does not significantly decrease the strength of association with laboratory-assessed biomarkers.
由于高发病率以及对生活质量的影响，上呼吸道感染对人群健康产生了重大影响。为了测试或比较治疗效果，需要一种精心设计且经过验证的针对特定疾病的生活质量评估工具。本研究报告的数据来自一项测试紫锥菊治疗诱发性鼻病毒感染的试验。实验室评估的生物标志物包括白细胞介素（IL）-8、鼻腔中性粒细胞计数（多形核中性粒细胞（PMN））、黏液重量、病毒滴度和血清转化。所使用的问卷包括一般健康简表（SF）-8（24小时回忆版）、八项杰克逊感冒量表以及44项威斯康星上呼吸道症状调查（WURSS）。共有399名参与者接种了鼻病毒，并在2088人日期间进行了监测。几乎所有变量之间都发现了具有统计学意义的关联。问卷之间的相关性如下：WURSS - 杰克逊量表 = 0.81；WURSS - SF - 8 = 0.62；杰克逊量表 - SF - 8 = 0.60。与实验室值的相关性如下：WURSS - 黏液重量 = 0.53；杰克逊量表 - 黏液重量 = 0.55；WURSS - 病毒滴度 = 0.37；杰克逊量表 - 病毒滴度 = 0.46；WURSS - IL - 8 = 0.31；杰克逊量表 - IL - 8 = 0.36；WURSS - PMN = 0.31；杰克逊量表 - PMN = 0.28。WURSS和杰克逊量表均未得出用于诊断感染的满意临界分数。上呼吸道感染的症状和生物学结果高度可变，关联性仅为中等程度。虽然威斯康星上呼吸道症状调查和杰克逊问卷都与生物标志物相关，但两者都不是诱发性感染的良好预测指标。威斯康星上呼吸道症状调查中纳入功能和生活质量项目并未显著降低与实验室评估生物标志物的关联强度。
