丙型肝炎病毒感染患者中免疫球蛋白GM和KM同种异型及抗LKM1自身抗体的流行情况。
Immunoglobulin GM and KM allotypes and prevalence of anti-LKM1 autoantibodies in patients with hepatitis C virus infection.
作者信息
Muratori Paolo, Sutherland Susan E, Muratori Luigi, Granito Alessandro, Guidi Marcello, Pappas Georges, Lenzi Marco, Bianchi Francesco B, Pandey Janardan P
机构信息
Department of Internal Medicine, Alma Mater Stadiorum-University of Bologna, Italy.
出版信息
J Virol. 2006 May;80(10):5097-9. doi: 10.1128/JVI.80.10.5097-5099.2006.
GM and KM allotypes-genetic markers of immunoglobulin (Ig) gamma and kappa chains, respectively-are associated with humoral immunity to several infection- and autoimmunity-related epitopes. We hypothesized that GM and KM allotypes contribute to the generation of autoantibodies to liver/kidney microsomal antigen 1 (LKM1) in hepatitis C virus (HCV)-infected persons. To test this hypothesis, we characterized 129 persons with persistent HCV infection for several GM and KM markers and for anti-LKM1 antibodies. The heterozygous GM 1,3,17 23 5,13,21 phenotype was significantly associated with the prevalence of anti-LKM1 antibodies (odds ratio, 5.13; P=0.002), suggesting its involvement in this autoimmune phenomenon in HCV infection.
GM和KM同种异型——分别是免疫球蛋白（Ig）γ链和κ链的遗传标记——与针对多种感染及自身免疫相关表位的体液免疫相关。我们推测，GM和KM同种异型在丙型肝炎病毒（HCV）感染者中促使了针对肝/肾微粒体抗原1（LKM1）自身抗体的产生。为验证这一推测，我们对129例持续性HCV感染者的多种GM和KM标记以及抗LKM1抗体进行了特征分析。杂合GM 1,3,17 23 5,13,21表型与抗LKM1抗体的流行率显著相关（优势比，5.13；P = 0.002），提示其参与了HCV感染中的这种自身免疫现象。
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