Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute and Department of Pathology, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.
Immunobiology. 2011 Jun;216(6):686-91. doi: 10.1016/j.imbio.2010.10.006. Epub 2010 Nov 5.
Genetic interactions between natural killer (NK) cells immunoglobulin-like receptor (KIR) genes and immunoglobulin allotypes have been previously reported in type 2 diabetes mellitus (DM) patients. Puerto Rican Americans with a history of intravenous drug use who developed DM following HCV infection (n=32) were compared to individuals infected with HCV without diabetes (n=121) and to DM non-infected individuals (n=95). Subjects were genotyped for KIRs and immunoglobulin allotypes. We found interactions of immunoglobulin allotypes KM3/KM3 with NK inhibitory receptors 2DL3/2DL3, 2DL1 in the absence of 2DS4 associated with susceptibility to DM in HCV infected individuals. These data suggest the possibility that a subset of patients with HCV could have an immune-mediated component contributing to the development of DM.
先前有研究报道，自然杀伤（NK）细胞免疫球蛋白样受体（KIR）基因与免疫球蛋白同种型之间存在遗传相互作用，在 2 型糖尿病（DM）患者中。与未感染 HCV 且无糖尿病的个体（n=121）和无 DM 感染个体（n=95）相比，曾有静脉吸毒史且 HCV 感染后发生 DM 的波多黎各裔美国人（n=32）被进行了 NK 抑制受体 2DL3/2DL3、2DL1 缺失情况下与 NK 抑制受体 2DL3/2DL3、2DL1 相关的 KM3/KM3 免疫球蛋白同种型的基因分型。我们发现，在 HCV 感染个体中，KM3/KM3 免疫球蛋白同种型与 NK 抑制受体 2DL3/2DL3、2DL1 的相互作用与 2DS4 缺失与 DM 易感性相关。这些数据表明，HCV 患者的一部分可能存在免疫介导的因素，导致 DM 的发生。
