Yang Jianli, Han Huili, Cui Minghu, Wang Liping, Cao Jun, Li Lingjiang, Xu Lin
Mental Health Institute of the 2nd Xiangya Hospital, Central South University, Changsha, PR China.
Neuroreport. 2006 May 15;17(7):753-7. doi: 10.1097/01.wnr.0000209044.66482.c5.
Behavioural stress facilitates long-term depression in Schaffer collaterals-CA1 pathway, but it is unknown whether it influences long-term depression in temporoammonic fibres-CA1. Here, we report that low-frequency stimulation induced long-term depression and foot shock stress before slice preparation facilitated long-term depression in both pathways of young rat slices. When the field excitatory postsynaptic potentials were recorded by stimulating the two pathways alternately and low-frequency stimulation was given to the two pathways simultaneously, a reliable long-term depression was induced in Schaffer collaterals-CA1 but a reliable long-term potentiation took place in temporoammonic fibres-CA1. Interestingly, foot shock stress now enabled low-frequency stimulation to induce reliable long-term depressions in both pathways. These findings suggested that acute behavioural stress facilitated long-term depressions in both pathways and disrupted the interactions between pathways.
