Bar-Meir Eran, Zaslansky Ruth, Regev Eli, Keidan Ilan, Orenstein Arie, Winkler Eyal
Department of Plastic and Reconstructive Surgery, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Plast Reconstr Surg. 2006 Apr 15;117(5):1571-5. doi: 10.1097/01.prs.0000206298.71083.df.
The purpose of this study was to investigate a means of providing pain relief during repair of facial lacerations in children in the emergency room.
This study was conducted in the emergency room of a tertiary care, university-affiliated hospital. Fifty percent nitrous oxide was administered by the surgeon who sutured the laceration. A nurse monitored the child throughout the procedure. At the end of the procedure, pain scores were evaluated by the surgeon and nurse using the FLACC (face, legs, activity, cry, and consolability) scale, a structured observational-behavioral scale for measurement of pain.
Sixty patients between the ages of 1 and 16 years participated in the study. Of these, 15 were sutured using standard care (lidocaine infiltration), and 45 children received nitrous oxide in addition to lidocaine infiltration. Nitrous oxide was administered for an average of 11.9 +/- 5.1 minutes (range, 4 to 30 minutes). Forty-three children recovered to preprocedure activity in less than 1 minute. Two children recovered in less than 3 minutes. Average FLACC scores during infiltration and suturing were significantly lower in the nitrous oxide group compared with controls (infiltration, 1.9 of 10 versus 9.7 of 10; suturing, 2 of 10 versus 8.8 of 10). Forceful restraining was necessary in all the controls, whereas in the nitrous oxide group mild force was required in only 15 percent. Seventy percent of the children receiving nitrous oxide had no side effects. Vomiting and nausea were the most common (17 percent), transient side effects. No respiratory or cardiovascular side effects occurred.
Nitrous oxide can be safely administered by plastic surgeons while suturing facial lacerations in the emergency room. The fast onset and rapid recovery characteristics of nitrous oxide provide a convenient environment for performing short surgical procedures. This safe method for provision of analgesia and anxiolysis may be appealing to plastic surgeons for ambulatory procedures (e.g., suture removal, expander inflation, Botox injection, injection of various fillers) in pediatric and adult populations.
本研究的目的是探究一种在急诊室为儿童面部裂伤修复提供疼痛缓解的方法。
本研究在一家三级医疗大学附属医院的急诊室进行。由缝合裂伤的外科医生给予50%的氧化亚氮。在整个手术过程中由一名护士对儿童进行监测。手术结束时,外科医生和护士使用FLACC(面部、腿部、活动、哭闹和安慰性)量表评估疼痛评分,这是一种用于测量疼痛的结构化观察行为量表。
60名年龄在1至16岁之间的患者参与了本研究。其中,15名采用标准护理(利多卡因浸润)进行缝合,45名儿童除利多卡因浸润外还接受了氧化亚氮。氧化亚氮的给药平均时间为11.9±5.1分钟(范围为4至30分钟)。43名儿童在不到1分钟内恢复到术前活动状态。2名儿童在不到3分钟内恢复。与对照组相比,氧化亚氮组在浸润和缝合过程中的平均FLACC评分显著更低(浸润:10分制中分别为1.9分和9.7分;缝合:10分制中分别为2分和8.8分)。所有对照组均需要强力约束,而在氧化亚氮组中只有15%需要轻度约束。接受氧化亚氮的儿童中有70%没有副作用。呕吐和恶心是最常见的(17%)短暂副作用。未发生呼吸或心血管副作用。
整形外科医生在急诊室缝合面部裂伤时可安全地给予氧化亚氮。氧化亚氮起效快和恢复迅速的特点为进行短时间外科手术提供了便利环境。这种提供镇痛和抗焦虑的安全方法可能对整形外科医生在儿科和成人患者的门诊手术(如拆线、扩张器充气、肉毒杆菌注射、各种填充物注射)中具有吸引力。