Najjar Dany M, Awwad Shady T, Zein Wadih M, Haddad Walid F
Department of Ophthalmology, Temple University Hospital, Philadelphia, PA 19140, USA.
Med Sci Monit. 2006 May;12(5):MT23-5.
The purpose of this prospective case-control study was to investigate whether exposure to ultraviolet (UV) light produces detectable damage to the corneal endothelium in patients presenting with acute UV keratitis.
MATERIAL/METHODS: Non-contact specular microscopy was performed on 20 consecutive patients who presented to our clinic from July 2000 to July 2002 with acute UV keratitis and similarly on 20 age-matched healthy controls. Both the coefficient of variation in mean cell size (CV) and the mean cell density (CD) were compared in these two groups using the Student t-test.
Mean age was 28.6 years in the study group and 28.4 years in the control group. The mean CD in the patient group was 2609.6 (SD = 103.47) and in the control group 2632.87 (SD = 117.05). No statistically significant difference was found between the mean CDs in these two groups (p = 0.93). The mean CV in the patient group was 46.7 (SD = 4.40) and in the control group 45.4 (SD = 5.60). Similarly, there was no statistically significant difference between the mean CVs in these two groups (p = 0.85).
UV light exposure does not seem to have a direct immediate effect on the corneal endothelium in humans with acute UV keratitis. Whether UV light produces cumulative and/or longer-term damage requires further studies with a larger number of patients and a longer follow-up time.
这项前瞻性病例对照研究的目的是调查急性紫外线角膜炎患者暴露于紫外线（UV）下是否会对角膜内皮产生可检测到的损伤。
材料/方法：对2000年7月至2002年7月间连续就诊于我们诊所的20例急性紫外线角膜炎患者以及20例年龄匹配的健康对照者进行非接触式镜面显微镜检查。使用学生t检验比较这两组的平均细胞大小变异系数（CV）和平均细胞密度（CD）。
研究组的平均年龄为28.6岁，对照组为28.4岁。患者组的平均CD为2609.6（标准差 = 103.47），对照组为2632.87（标准差 = 117.05）。两组的平均CD之间未发现统计学上的显著差异（p = 0.93）。患者组的平均CV为46.7（标准差 = 4.40），对照组为45.4（标准差 = 5.60）。同样，两组的平均CV之间也没有统计学上的显著差异（p = 0.85）。
对于患有急性紫外线角膜炎的人，紫外线暴露似乎不会对角膜内皮产生直接的即时影响。紫外线是否会产生累积和/或长期损伤需要通过对更多患者进行更长时间随访的进一步研究来确定。
