Moore Charleen M, Hubbard Gene B, Leland M Michelle, Dunn Betty G, Barrier Breton F, Siler-Khodr Theresa M, Schlabritz-Loutsevitch Natalia E
Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, USA.
J Am Assoc Lab Anim Sci. 2006 May;45(3):58-62.
A 6-y-old female baboon was examined due to absence of menstrual cycling and secondary sex characteristics and failure to reproduce. The mammary glands and vaginal introitus were hypoplastic, the clitoris was prominent, and the perineal skin was immature with lack of cyclic color alterations and sexual swelling. Evaluation of the reproductive tract revealed a hypoplastic uterus and rudimentary ovaries with the presence of an ovarian leiomyoma within the right ovary. Hormonal values (estradiol, progesterone) were low and comparable to those of adult males or ovariectomized females. Adrenal and pituitary hormones (dehydroepiandrosterone, luteinizing and follicular stimulating hormones) and pituitary structure were within normal limits for this species. The baboon had a normal 42,XX karyotype. These findings suggest primary amenorrhea due to ovarian dysgenesis. This is the first report of a case of primary amenorrhea due to ovarian dysgenesis with a normal karyotype associated with a unilateral ovarian leiomyoma in the baboon. Continued studies of noncycling female nonhuman primates in captive breeding colonies may lead to a greater understanding of the underlying causes of this condition.
一只6岁的雌性狒狒因无月经周期和第二性征以及无法繁殖而接受检查。乳腺和阴道口发育不全，阴蒂突出，会阴皮肤不成熟，缺乏周期性颜色变化和性肿胀。生殖道评估显示子宫发育不全和卵巢发育不全，右侧卵巢内有一个卵巢平滑肌瘤。激素值（雌二醇、孕酮）较低，与成年雄性或去卵巢雌性相当。肾上腺和垂体激素（脱氢表雄酮、黄体生成素和促卵泡激素）以及垂体结构在该物种的正常范围内。这只狒狒的核型正常，为42,XX。这些发现提示由于卵巢发育不全导致原发性闭经。这是第一例关于狒狒因卵巢发育不全导致原发性闭经且核型正常并伴有单侧卵巢平滑肌瘤的病例报告。对圈养繁殖群体中无月经周期的雌性非人灵长类动物的持续研究可能会使我们对这种情况的潜在原因有更深入的了解。
