樟芝子实体中的神经保护二萜类化合物。

Neuroprotective diterpenes from the fruiting body of Antrodia camphorata.

作者信息

Chen Cheng-Chi, Shiao Young-Ji, Lin Ruei-Da, Shao Yi-Yuan, Lai Min-Nan, Lin Chun-Ching, Ng Lean-Teik, Kuo Yueh-Hsiung

机构信息

Department of Chemistry, National Taiwan University, Taipei, Taiwan 106.

出版信息

J Nat Prod. 2006 Apr;69(4):689-91. doi: 10.1021/np0581263.

DOI:10.1021/np0581263

PMID:16643055

Abstract

Three new compounds, 19-hydroxylabda-8(17)-en-16,15-olide (1), 3beta,19-dihydroxylabda-8(17),11E-dien-16,15-olide (2), and 13-epi-3beta,19-dihydroxylabda-8(17),11E-dien-16,15-olide (3), together with four known compounds, 19-hydroxylabda-8(17),13-dien-16,15-olide (4), 14-deoxy-11,12-didehydroandrographolide (5), 14-deoxyandrographolide, and pinusolidic acid, were isolated from the fruiting bodies of Antrodia camphorata. The structures of compounds 1-3 were elucidated by the analysis of their spectroscopic data. The in vitro neuroprotective activity of all compounds was evaluated, and compounds 1-5 protected neurons from Abeta damage by 39.2, 35.0, 36.7, 30.6, and 27.0%, respectively, at concentrations between 5 and 20 microM.

摘要

从樟芝子实体中分离出三种新化合物，19 - 羟基-labda - 8(17)-烯-16,15 - 内酯(1)、3β,19 - 二羟基-labda - 8(17),11E - 二烯-16,15 - 内酯(2)和13 - 表-3β,19 - 二羟基-labda - 8(17),11E - 二烯-16,15 - 内酯(3)，以及四种已知化合物，19 - 羟基-labda - 8(17),13 - 二烯-16,15 - 内酯(4)、14 - 脱氧-11,12 - 二脱氢穿心莲内酯(5)、14 - 脱氧穿心莲内酯和松脂酸。通过对化合物1 - 3的光谱数据分析阐明了其结构。评估了所有化合物的体外神经保护活性，在5至20微摩尔浓度下，化合物1 - 5分别使神经元免受Aβ损伤的比例为39.2%、35.0%、36.7%、30.6%和27.0%。