来自曼氏陀螺果的二萜类化合物。

Diterpenoids from Turraeanthus mannii.

作者信息

Vardamides Juliette Catherine, Sielinou Valerie Tedjon, Ndemangou Brigitte, Nkengfack Augustin Ephrem, Fomum Zacharias Tanee, Poumale Herve Martial Poumale, Laatsch Hartmut

机构信息

Department of Organic Chemistry, University of Douala, Douala, Cameroon.

出版信息

Planta Med. 2007 May;73(5):491-5. doi: 10.1055/s-2007-967170.

DOI:10.1055/s-2007-967170

PMID:17566150

Abstract

Three new compounds, 15-acetoxy-12-hydroxy-16-methyl-labda-8(17),13E-diene (1), ent-labda-8(17),13-dien-15,16-olid-19-oic acid methyl ester (2), and 12-hydroxy-labda-8(17),13-dien-15,16-olide (3), together with two known compounds, 19-acetoxy-ent-labda-8(17),13-dien-15,16-olide (4), and 16-acetoxy-12,15-epoxy-15beta-hydroxy-labda-8(17),13(16)-diene (5) were isolated from the stem bark of Turraeanthus mannii (Meliaceae). The structures of compounds 1 - 3 were elucidated by analysis of the spectroscopic data. The crude methanol extract and compound 5 exhibited weak antibacterial and antifungal activity.

摘要

从楝科植物曼氏杜楝（Turraeanthus mannii）的茎皮中分离出三种新化合物，即15-乙酰氧基-12-羟基-16-甲基-喇叭茶-8(17),13E-二烯（1）、对映-喇叭茶-8(17),13-二烯-15,16-内酯-19-甲酸甲酯（2）和12-羟基-喇叭茶-8(17),13-二烯-15,16-内酯（3），以及两种已知化合物，19-乙酰氧基-对映-喇叭茶-8(17),13-二烯-15,16-内酯（4）和16-乙酰氧基-12,15-环氧-15β-羟基-喇叭茶-8(17),13(16)-二烯（5）。通过光谱数据分析阐明了化合物1 - 3的结构。粗甲醇提取物和化合物5表现出较弱的抗菌和抗真菌活性。