米诺环素诱导的皮肤色素沉着：共聚焦激光扫描显微镜分析
Minocycline-induced cutaneous hyperpigmentation: confocal laser scanning microscope analysis.
作者信息
Dodiuk-Gad R P, de Morentin H M, Schafer J, Harel A, Neudorfer M, Misonzhnik F, Gitstein G, Rozenman D, Tur E, Brenner S
机构信息
Department of Dermatology, Ha'emek Medical Center, Afula, Israel.
出版信息
J Eur Acad Dermatol Venereol. 2006 Apr;20(4):435-9. doi: 10.1111/j.1468-3083.2006.01436.x.
BACKGROUND
Minocycline has a characteristic yellow-green fluorescent emission. This fluorescence has been previously demonstrated only in type 1 minocycline-induced skin hyperpigmentation.
OBJECTIVE
To investigate whether the fluorescence can be detected in other types of minocycline-induced cutaneous hyperpigmentation, and to study the possible mechanisms.
METHODS
Biopsies of pigmented and nonpigmented skin from 3 patients with different types of skin hyperpigmentation induced by minocycline were analysed by light microscopy and Confocal Laser Scanning Microscope (CLSM).
RESULTS
A yellow-green fluorescence was observed in the hyperpigmented skin of two patients with type 2, and one patient with type 4 minocycline-induced cutaneous hyperpigmentation. No fluorescence was detected in the non-pigmented skin.
CONCLUSION
Minocycline can possibly serve as a fluorescent probe in the diagnosis of all types of minocycline-induced cutaneous hyperpigmentation.
背景
米诺环素具有特征性的黄绿荧光发射。此前这种荧光仅在1型米诺环素诱导的皮肤色素沉着中被证实。
目的
研究其他类型米诺环素诱导的皮肤色素沉着中是否能检测到该荧光，并探讨其可能机制。
方法
对3例不同类型米诺环素诱导皮肤色素沉着患者的色素沉着皮肤和非色素沉着皮肤活检标本进行光学显微镜和共聚焦激光扫描显微镜（CLSM）分析。
结果
在2例2型和1例4型米诺环素诱导的皮肤色素沉着患者的色素沉着皮肤中观察到黄绿荧光。非色素沉着皮肤中未检测到荧光。
结论
米诺环素可能作为一种荧光探针用于诊断所有类型的米诺环素诱导的皮肤色素沉着。
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