Rahman Zakia, Lazova Rossitza, Antaya Richard J
Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520-8059, USA.
J Cutan Pathol. 2005 Aug;32(7):516-9. doi: 10.1111/j.0303-6987.2005.00369.x.
We present a 15-year-old girl with bilateral lower extremity discoloration of one-year duration while taking minocycline for acne vulgaris. The clinical characteristics best supported type II minocycline hyperpigmentation, but the histology revealed that the pigmentation was solely limited to the subcutaneous adipose tissue, completely sparing the dermis. Special stain for iron was negative. This is the first case to our knowledge with pigment exclusively located in the subcutaneous fat and with the unusual finding of a negative stain for iron.
我们报告一名15岁女孩，在服用米诺环素治疗寻常痤疮一年后出现双下肢色素沉着。临床特征最符合II型米诺环素色素沉着，但组织学检查显示色素沉着仅局限于皮下脂肪组织，真皮完全未受累。铁特殊染色为阴性。据我们所知，这是首例色素仅位于皮下脂肪且铁染色结果异常为阴性的病例。
