Akar A Ruchan, Durdu Serkan, Corapcioglu Tumer, Ozyurda Umit
Department of Cardiovascular Surgery, Heart Center, Ankara University School of Medicine and Ankara University Biotechnology Institute, Turkey.
Artif Organs. 2006 Apr;30(4):213-32. doi: 10.1111/j.1525-1594.2006.00209.x.
Cardiovascular disorders are the leading causes of mortality and morbidity in the developed world. Cell-based modalities have received considerable scientific attention over the last decade for their potential use in this clinical arena. This review was intended as a brief overview on the subject of therapeutic potential of adult stem cells in cardiovascular medicine with basic science findings and the current status of clinical applications. The historical perspective and basic concepts are reviewed and a description of current applications and potential adverse effects in cardiovascular medicine is given. Future improvements on cell-based therapies will likely provide remarkable improvement in survival and quality of life for millions of patients with cardiovascular disorders.
心血管疾病是发达国家致死和致残的主要原因。在过去十年中，基于细胞的治疗方法因其在这一临床领域的潜在应用而受到了相当多的科学关注。这篇综述旨在简要概述成体干细胞在心血管医学中的治疗潜力，包括基础科学研究结果和临床应用现状。文中回顾了历史背景和基本概念，并描述了心血管医学中当前的应用情况以及潜在的不良反应。基于细胞的治疗方法未来的改进可能会为数百万心血管疾病患者的生存和生活质量带来显著改善。
