Moreau L, Servant A, Valcke J
Sem Hop. 1975 Jan 8;51(2):109-16.
The authors report 4 personal cases, and analyse 18 cases of anterior pituitary insufficiency in the elderly found in the world literature. The initial symptoms are not specific and are difficult to interpret. They are frequently attributed to physiological ageing. In the absence of early diagnois, the patient may become comatose, this coma is often irreversible in spite of hormone treatment. In 60% of cases, the cause of the pituitary failure was not found. In the onset of the latter, the role of ageing on pituitary function, the responsibility of circulatory failure between the hypothalamus and the pituitary and, finally, the existence of auto-immune mechanisms are then discussed.
作者报告了4例个人病例，并分析了世界文献中发现的18例老年人垂体前叶功能减退病例。初始症状不具特异性，难以解读。这些症状常被归因于生理衰老。若未早期诊断，患者可能会陷入昏迷，尽管进行激素治疗，这种昏迷往往不可逆。60%的病例中未发现垂体功能衰竭的原因。随后讨论了垂体功能衰竭发病时衰老对垂体功能的作用、下丘脑与垂体之间循环衰竭的责任，以及自身免疫机制的存在情况。
