Vlasov S G, Storozhenko I V, Khak A M, Koshelev V B, Riasina T V, Medvedev O S
Fiziol Zh SSSR Im I M Sechenova. 1991 Apr;77(4):52-8.
Changes in arterial pressure (AP) and venous tone were studied in Krushinskiĭ-Molodkina (KM) rats genetically predisposed to audiogenic seizure, during the audio stress and 20 min after it. The venous tone was estimated by the mean circulatory filling pressure (MCFP) during a short arrest of circulation by inflating a balloon in the right atrium. It was shown that, during seizure, AP raised from 104 to 156 mm Hg on the average, while MCFP decreased from 8.9 to 7.4 mm Hg. Ganglion blockade with hexamethonium did not prevent the development of pressor reaction during seizure. The intensity of subdural and subarachnoidal hemorrhagic correlates with the raise of AP during seizure. The hemorrhagic area spread over 75 mm2 during AP greater than 200 m Hg, while in lower increment it was only 2.56 mm2. The KM rats can be used in experimental modelling of brain circulation disorders caused by acute increase in AP.
在对声音性癫痫发作具有遗传易感性的克鲁申斯基-莫洛金娜（KM）大鼠中，研究了声音应激期间及之后20分钟动脉压（AP）和静脉张力的变化。通过在右心房内充气气球使循环短暂停止期间的平均循环充盈压（MCFP）来估计静脉张力。结果表明，在癫痫发作期间，AP平均从104毫米汞柱升至156毫米汞柱，而MCFP从8.9毫米汞柱降至7.4毫米汞柱。用六甲铵进行神经节阻滞并不能阻止癫痫发作期间升压反应的发生。硬膜下和蛛网膜下出血的强度与癫痫发作期间AP的升高相关。当AP大于200毫米汞柱时，出血面积超过75平方毫米，而在升高幅度较低时，出血面积仅为2.56平方毫米。KM大鼠可用于急性AP升高引起的脑循环障碍的实验模型研究。
