Bach Jean-François
INSERM U580, Hôpital Necker, 161, rue de Sèvres, 75015 Paris, France.
C R Biol. 2006 Apr;329(4):260-2. doi: 10.1016/j.crvi.2005.12.007. Epub 2006 Apr 4.
Immunologic tolerance is a state of immune paralysis specific to a given antigen (the tolerogen) coexisting with the maintenance of normal immunocompetence towards other antigens. Anti-T cell monoclonal antibodies allow its induction in organ transplantation and autoimmune disease essentially through the stimulation of regulatory T cells. Very promising results obtained in animals have been recently confirmed in the human in recent-onset insulin-dependent diabetes mellitus with an anti-CD3 antibody (with long-term remission of the disease following a treatment of only six days).
免疫耐受是一种针对特定抗原（耐受原）的免疫麻痹状态，同时保持对其他抗原的正常免疫活性。抗T细胞单克隆抗体主要通过刺激调节性T细胞，在器官移植和自身免疫性疾病中诱导免疫耐受。最近在动物实验中获得的非常有前景的结果，已在新发胰岛素依赖型糖尿病患者中得到证实，使用抗CD3抗体（仅治疗六天疾病就长期缓解）。
