Waldmann H, Cobbold S
Immunology Division, Dept of Pathology, Cambridge, UK.
Immunol Today. 1993 Jun;14(6):247-51. doi: 10.1016/0167-5699(93)90040-R.
Monoclonal antibodies are potentially useful immunosuppressive agents. Short courses of CD4/CD8 monoclonal antibody can be used to guide the immune system of experimental animals to accept organ grafts and to arrest autoimmunity. This reprogramming is accompanied by potent T-cell dependent, 'infectious' regulatory mechanisms. A goal for therapeutic immunosuppression should be to understand and harness these innate immunoregulatory mechanisms.
单克隆抗体是潜在有用的免疫抑制剂。短疗程的CD4/CD8单克隆抗体可用于引导实验动物的免疫系统接受器官移植并阻止自身免疫。这种重新编程伴随着强大的T细胞依赖性“传染性”调节机制。治疗性免疫抑制的一个目标应该是理解并利用这些先天免疫调节机制。
