Bhadra A K, Casey A T H
National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK.
J Bone Joint Surg Br. 2006 May;88(5):634-6. doi: 10.1302/0301-620X.88B5.17299.
We have treated 175 patients with a chordoma over a ten-year period. Only two had a family history of the condition and we describe these in this paper. In one patient the tumour was at the craniocervical junction and in the other the lesion affected the sacrum. We have undertaken a literature review of familial chordoma and have identified chromosomal abnormalities associated with the condition.
在十年间，我们共治疗了175例脊索瘤患者。其中仅有两例有该病的家族病史，本文将对这两例进行描述。一例患者的肿瘤位于颅颈交界处，另一例患者的病变累及骶骨。我们对家族性脊索瘤进行了文献综述，并确定了与该病相关的染色体异常。
