Lau-Cam C A, Thadikonda K P, Kendall B F
Department of Pharmaceutical Sciences College of Pharmacy and Allied Health Professions St. John's University Jamaica, NY 11439.
Res Commun Chem Pathol Pharmacol. 1991 Aug;73(2):197-207.
The administration of a single, 100-300 mg/kg ip, dose of a B6 vitamer to rats resulted in an almost immediate and gradual mobilization of the liver glycogen and a concomitant elevation of the serum glucose, with the order of potency being pyridoxal greater than pyridoxamine greater than pyridoxine. Since the B6 vitamer also stimulated the secretion of adrenal catecholamines and the accumulation of liver cAMP, and a pretreatment with selected blocking agents conferred significant protection against the glycogen depletion in the order of potency propranolol + phentolamine greater than propranolol greater than verapamil greater than phentolamine, a role for an adrenomedullary catecholamine-stimulated, beta-adrenoceptor-mediated, activation of the glycogen cascade system was suggested. This assumption was confirmed by verifying pyridoxal to possess virtually no effect on the liver glycogen of adrenalectomized rats.
给大鼠腹腔注射100 - 300毫克/千克的单一剂量维生素B6会导致肝脏糖原几乎立即且逐渐地动员，同时血清葡萄糖升高，其效力顺序为吡哆醛大于吡哆胺大于吡哆醇。由于维生素B6还刺激肾上腺儿茶酚胺的分泌和肝脏环磷酸腺苷（cAMP）的积累，并且用选定的阻断剂进行预处理能以普萘洛尔 + 酚妥拉明大于普萘洛尔大于维拉帕米大于酚妥拉明的效力顺序对糖原耗竭提供显著保护，因此提示肾上腺髓质儿茶酚胺刺激的、β - 肾上腺素能受体介导的糖原级联系统激活起了作用。通过证实吡哆醛对肾上腺切除大鼠的肝脏糖原几乎没有影响，这一假设得到了证实。
