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Modification of histogenetic processes in rat nervous tissue after administration of dexamethasone during prenatal development.

作者信息

Korzhevskii D E, Gilerovich E G, Khozhai L I, Grigor'ev I P, Otellin V A

机构信息

Department of Morphology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg.

出版信息

Neurosci Behav Physiol. 2006 Jun;36(5):537-9. doi: 10.1007/s11055-006-0052-6.

DOI:10.1007/s11055-006-0052-6
PMID:16645770
Abstract

Experiments on rats using confocal microscopy and immunocytochemistry showed that single doses of the synthetic corticosteroid hormone dexamethasone to pregnant females during the period of elevated sensitivity of the developing fetal nervous system (day 13 of intrauterine development) led to modification of histogenetic processes in the brain, reflected as changes in its structural-functional characteristics during postnatal ontogenesis.

摘要

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本文引用的文献

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Choice and dose of corticosteroid for antenatal treatments.产前治疗中皮质类固醇的选择和剂量。
Am J Obstet Gynecol. 2004 Apr;190(4):878-81. doi: 10.1016/j.ajog.2004.01.044.
2
[Formation of neocortex in rats after prenatal hypoxia].[产前缺氧后大鼠新皮质的形成]
Morfologiia. 2002;122(5):34-8.
3
[Proliferative zones of the epithelium of human embryonic brain choroid plexuses].
Morfologiia. 1999;115(3):38-41.
4
Glucocorticoid administration alters nuclear transcription factors in fetal rat brain: implications for the use of antenatal steroids.
Brain Res Dev Brain Res. 1998 Nov 1;111(1):11-24. doi: 10.1016/s0165-3806(98)00115-1.