Shu Yong-Qian, Gu Yanhong
Department of Oncology, the First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China.
Biomed Pharmacother. 2006 May;60(4):156-60. doi: 10.1016/j.biopha.2006.03.001. Epub 2006 Mar 31.
To study the effect of OK-432 on the maturation and function of human peripheral blood monocyte-derived dendritic cells, and the effect of these dendritic cells on the proliferation and anti-tumor function of cytokine induced killers.
Through the analysis of DCs' surface molecules, the detection of the proliferation and anti-tumor function of CIKs activated by DCs, we researched the influence of OK-432 on DCs and CIKs.
OK-432 have the potential of promoting DCs to express CD1a, CD80, CD83, HLA-DR highly, which is stronger than LPS; DCs activated by OK-432 can facilitate the proliferation and function of CIKs.
OK-432 can induce DCs' maturation and can thus promote CIKs' functions.
研究溶链菌制剂（OK-432）对人外周血单核细胞来源树突状细胞成熟及功能的影响，以及这些树突状细胞对细胞因子诱导的杀伤细胞增殖和抗肿瘤功能的影响。
通过分析树突状细胞表面分子，检测由树突状细胞激活的细胞因子诱导的杀伤细胞的增殖及抗肿瘤功能，研究溶链菌制剂对树突状细胞和细胞因子诱导的杀伤细胞的影响。
溶链菌制剂有促进树突状细胞高表达CD1a、CD80、CD83、HLA-DR的潜能，且强于脂多糖；经溶链菌制剂激活的树突状细胞可促进细胞因子诱导的杀伤细胞的增殖及功能。
溶链菌制剂可诱导树突状细胞成熟，从而促进细胞因子诱导的杀伤细胞的功能。
