• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Glutathione depletion of stimulator cells inhibits responder T-cell immunogenicity in vitro and prolongs allograft survival in vivo.

作者信息

McKenna Gregory J, Kim Peter T W, Mui Alice L F, Ong Christopher J, Rotstein Ori D, Warnock Garth L, Chung Stephen W

机构信息

Department of Surgery, University of British Columbia, 3100-910 West 10th Avenue, Vancouver, BC, Canada, V5Z 4E3.

出版信息

Am J Surg. 2006 May;191(5):588-92. doi: 10.1016/j.amjsurg.2006.02.006.

DOI:10.1016/j.amjsurg.2006.02.006
PMID:16647342
Abstract

BACKGROUND

Pretransplant donor-organ immunomodulation may attenuate allograft rejection by changing the redox state of donor cells. This study explored impact of donor-cell redox-state alteration by glutathione (GSH) depletion on graft immunogenicity.

METHODS

Splenic and heart endothelial cells from Balb/c mice were treated with diethylmaleate (a GSH-depleting agent) and/or lipopolysaccharide to assess the impact of GSH depletion on alloreactivity by mixed lymphocyte reaction, endothelial cell adhesion by T-cell adhesion assay, intracellular adhesion molecule-1 expression by reverse transcriptionase-polymerase chain reaction, and nuclear factor-kappa B upregulation by electrophoretic mobility shift assay. Heterotopic heart transplants were performed as in vivo correlate.

RESULTS

GSH depletion decreased endothelial cell and splenic cell alloreactivity, decreased endothelial cell intracellular adhesion molecule-1 expression through attenuation of nuclear factor-kappa B activity, decreased endothelial cell adhesion, and prolonged heterotopic heart transplant graft survival.

CONCLUSIONS

GSH depletion may represent a significant immunomodulator of donor antigenicity to prevent transplant rejection.

摘要

相似文献

1
Glutathione depletion of stimulator cells inhibits responder T-cell immunogenicity in vitro and prolongs allograft survival in vivo.
Am J Surg. 2006 May;191(5):588-92. doi: 10.1016/j.amjsurg.2006.02.006.
2
Pretreatment of donor stimulator cells by 16,16 dimethyl prostaglandin E2 influences the recipient immune response.用16,16 - 二甲基前列腺素E2对供体刺激细胞进行预处理会影响受体的免疫反应。
Surgery. 1998 Feb;123(2):171-80.
3
Prolonged heart allograft survival resulted from donor-specific T-cell sequestering and removal by selective splenectomy in mice.在小鼠中，通过选择性脾切除术进行供体特异性T细胞隔离和清除，可延长心脏移植的存活时间。
Transplant Proc. 2004 Oct;36(8):2448-9. doi: 10.1016/j.transproceed.2004.08.124.
4
Overexpression of program death-1 in T cells has mild impact on allograft survival.T细胞中程序性死亡-1的过表达对同种异体移植物存活有轻微影响。
Transpl Int. 2008 Jan;21(1):21-9. doi: 10.1111/j.1432-2277.2007.00536.x.
5
Impact of vaccine therapy using nuclear histone H1 on allograft survival in experimental organ transplantation.使用核组蛋白H1的疫苗疗法对实验性器官移植中同种异体移植物存活的影响。
Transpl Immunol. 2007 Apr;17(3):147-52. doi: 10.1016/j.trim.2007.01.003. Epub 2007 Jan 24.
6
FK778, a novel immunosuppressive agent, reduces early adhesion molecule up-regulation and prolongs cardiac allograft survival.新型免疫抑制剂FK778可减少早期黏附分子上调并延长心脏移植存活时间。
Transpl Int. 2005 Feb;18(2):215-20. doi: 10.1111/j.1432-2277.2004.00044.x.
7
STAT-1 and AP-1 decoy oligonucleotide therapy delays acute rejection and prolongs cardiac allograft survival.信号转导和转录激活因子1（STAT-1）及活化蛋白1（AP-1）诱饵寡核苷酸疗法可延缓急性排斥反应并延长心脏移植存活时间。
Cardiovasc Res. 2006 Aug 1;71(3):527-36. doi: 10.1016/j.cardiores.2006.05.021. Epub 2006 May 27.
8
[Pretreatment of donor dendritic cells with NBD-peptide prolongs mouse cardiac allograft survival].用NBD肽预处理供体树突状细胞可延长小鼠心脏同种异体移植的存活时间
Nan Fang Yi Ke Da Xue Xue Bao. 2008 Aug;28(9):1562-7.
9
Pioglitazone prevents acute and chronic cardiac allograft rejection.吡格列酮可预防心脏同种异体移植的急性和慢性排斥反应。
Circulation. 2006 Jun 6;113(22):2613-22. doi: 10.1161/CIRCULATIONAHA.105.594101. Epub 2006 May 30.
10
Effect of bamboo culm extract on oxidative stress and genetic expression: bamboo culm extract ameliorates cell adhesion molecule expression and NFkappaB activity through the suppression of the oxidative stress.竹茎提取物对氧化应激和基因表达的影响：竹茎提取物通过抑制氧化应激改善细胞粘附分子表达和核因子κB活性。
Clin Nutr. 2008 Oct;27(5):755-63. doi: 10.1016/j.clnu.2008.06.002. Epub 2008 Jul 17.

引用本文的文献

1
Strategic faculty recruitment increases research productivity within an academic university division.战略性的教师招聘提高了学术性大学部门内的研究生产力。
Can J Surg. 2009 Oct;52(5):401-6.