阿立哌唑与氯氮平联用的益处：三例病例报告
Benefits of combining aripiprazole to clozapine: three case reports.
作者信息
Rocha Fábio Lopes, Hara Cláudia
机构信息
Rua dos Otoni, 106, Santa Efigênia, 30150.270, Belo Horizonte, MG, Brazil.
出版信息
Prog Neuropsychopharmacol Biol Psychiatry. 2006 Aug 30;30(6):1167-9. doi: 10.1016/j.pnpbp.2006.03.024. Epub 2006 May 2.
OBJECTIVE
A substantial number of patients treated with clozapine shows insufficient response. The author presents the results of adding aripiprazole in patients resistant to clozapine.
METHOD
Three cases of individuals with psychotic symptoms despite clozapine use and with significant side effects that were treated via this combination are presented. Response was evaluated by clinical assessment.
RESULTS
Good clinical results were obtained in all three patients, with improvement of psychotic symptoms and of some of the side effects of clozapine.
CONCLUSION
The findings from this case series suggest that adjunctive therapy with aripiprazole can be of benefit for treating clozapine resistant schizophrenic patients.
目的
大量接受氯氮平治疗的患者显示反应不足。作者呈现了在对氯氮平耐药的患者中添加阿立哌唑的结果。
方法
介绍了3例尽管使用氯氮平仍有精神病症状且有显著副作用并通过这种联合治疗的个体。通过临床评估来评估反应。
结果
所有3例患者均取得了良好的临床效果，精神病症状以及氯氮平的一些副作用均有所改善。
结论
该病例系列的研究结果表明，阿立哌唑辅助治疗可能有益于治疗对氯氮平耐药的精神分裂症患者。
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