Dobrovský K, Valchár M, Höschl C
Výzkumný ústav pro farmacii a biochemii, Praha.
Cas Lek Cesk. 1991 Nov 29;130(22-23):625-30.
The role of calcium as a second messenger which mediates the transmission of the signal and has an impact on cellular regulation of the majority of organs at all stages of development was confirmed during the past decade. In the submitted review the authors summarize mechanisms by which calcium exerts its regulatory function. At the same time the authors discuss the possible ratio of disorders in the above systems in various diseases in particular those of the central nervous system and possible pharmacotherapeutic interferences at different levels of transmission of the signal mediated by calcium. As in the mentioned area at the clinical level so far mainly calcium channel blockers were used, the authors summarize the use of these substances in the treatment of cerebral ischaemia, migraine, epilepsy and manic-depressive disease.
在过去十年中，钙作为第二信使的作用得到了证实，它介导信号传递，并在发育的各个阶段对大多数器官的细胞调节产生影响。在提交的综述中，作者总结了钙发挥其调节功能的机制。同时，作者讨论了上述系统在各种疾病，特别是中枢神经系统疾病中可能出现的紊乱比例，以及在钙介导的信号传递的不同水平上可能的药物治疗干预。由于在临床层面的上述领域，目前主要使用钙通道阻滞剂，作者总结了这些物质在治疗脑缺血、偏头痛、癫痫和躁郁症中的应用。
