减数分裂与性染色体非整倍体：减数分裂错误如何导致非整倍体；非整倍体如何导致减数分裂错误。
Meiosis and sex chromosome aneuploidy: how meiotic errors cause aneuploidy; how aneuploidy causes meiotic errors.
作者信息
Hall Heather, Hunt Patricia, Hassold Terry
机构信息
School of Molecular Biosciences and the Center for Reproductive Biology, Washington State University, Pullman WA 99164, USA.
出版信息
Curr Opin Genet Dev. 2006 Jun;16(3):323-9. doi: 10.1016/j.gde.2006.04.011. Epub 2006 May 2.
As a group, sex chromosome aneuploidies - the 47,XXY, 47,XYY, 47,XXX and 45,X conditions - constitute the most common class of chromosome abnormality in human live-births. Considerable attention has been given to the somatic abnormalities associated with these conditions, but less is known about their meiotic phenotypes; that is, how does sex chromosome imbalance influence the meiotic process. This has become more important with the advent of assisted reproductive technologies, because individuals previously thought to be infertile can now become biological parents. Indeed, there are several recent reports of successful pregnancies involving 47,XXY fathers, and suggestions that cryopreservation of ovarian tissue might impart fertility to at least some Turner syndrome individuals. Thus, the possible consequences of sex chromosome aneuploidy on meiotic chromosome segregation need to be explored.
作为一个群体，性染色体非整倍体——47,XXY、47,XYY、47,XXX和45,X情况——是人类活产中最常见的染色体异常类型。人们已经相当关注与这些情况相关的躯体异常，但对它们的减数分裂表型了解较少；也就是说，性染色体失衡如何影响减数分裂过程。随着辅助生殖技术的出现，这一点变得更加重要，因为以前被认为不育的个体现在可以成为生物学父母。事实上，最近有几篇关于47,XXY父亲成功怀孕的报道，并且有人提出卵巢组织冷冻保存可能会使至少一些特纳综合征个体获得生育能力。因此，需要探索性染色体非整倍体对减数分裂染色体分离的可能影响。
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