Wingo Shana N, Knowles Lynne M, Carrick Kelley S, Miller David S, Schorge John O
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9032, USA.
Am J Obstet Gynecol. 2006 May;194(5):e20-2. doi: 10.1016/j.ajog.2005.11.033. Epub 2006 Apr 21.
The purpose of this study was to determine the benefit of surgically staging ovarian low malignant potential tumors.
This was a retrospective cohort study of all ovarian low malignant potential tumors that were diagnosed by frozen section or final pathologic review from 2003 to 2005.
Twenty-two of 32 patients (69%) were staged surgically. Sixteen low malignant potential tumors were stage I by final pathologic review, and 4 tumors were upstaged to stage II-III disease. Two other patients had early invasive ovarian carcinoma, despite a frozen section that suggested low malignant potential; 1 patient received adjuvant chemotherapy. The tumors of 10 women (31%) were unstaged. Frozen section suspicion of low malignant potential (P = .003) and surgery by a gynecologic oncologist (P < .001) correlated with staging. Preoperative CA-125, intraoperative blood loss, and postoperative hospitalization were increased in patients with staged disease (each P < .05). Two women who underwent fertility-sparing surgery experienced a recurrence in the contralateral ovary.
Surgical staging of ovarian low malignant potential tumors has limited value for most patients, unless invasive carcinoma is diagnosed by final pathologic review.
本研究旨在确定对卵巢低恶性潜能肿瘤进行手术分期的益处。
这是一项回顾性队列研究，研究对象为2003年至2005年期间通过冰冻切片或最终病理检查确诊的所有卵巢低恶性潜能肿瘤。
32例患者中有22例（69%）接受了手术分期。最终病理检查显示，16例低恶性潜能肿瘤为I期，4例肿瘤分期上调至II - III期疾病。另外2例患者尽管冰冻切片提示低恶性潜能，但最终确诊为早期浸润性卵巢癌；1例患者接受了辅助化疗。10名女性（31%）的肿瘤未进行分期。冰冻切片怀疑为低恶性潜能（P = .003）以及由妇科肿瘤学家进行手术（P < .001）与分期相关。分期患者的术前CA - 125、术中失血量和术后住院时间均增加（P均 < .05）。2例接受保留生育功能手术的女性对侧卵巢出现复发。
对于大多数患者，卵巢低恶性潜能肿瘤的手术分期价值有限，除非最终病理检查确诊为浸润性癌。
