Melo M A B, Meseguer M, Garrido N, Bosch E, Pellicer A, Remohí J
Instituto Valenciano de Infertilidad, Universidad de Valencia, Valencia, Spain.
Hum Reprod. 2006 Jun;21(6):1503-7. doi: 10.1093/humrep/dei474. Epub 2006 Apr 28.
Several evidences indicate that premature luteinization (PL) may affect IVF outcome. The primary end-point of the present study was to verify the effect of PL on the pregnancy rate (PR) of our oocyte-donation programme.
PL was defined as serum progesterone > or = 1.2 ng/ml on the day of HCG. We analysed retrospectively 240 oocyte-donation cycles in which 120 women donated twice, with PL in the first donation cycle and no PL in the following one, acting as its own control. Recipients (n = 240) were divided in two groups according to the presence of PL (n = 120) or not (n = 120). Both groups were compared regarding donor cycle parameters and recipient cycle outcome.
There was no difference in PR between the groups (55.7 versus 54.4%, respectively). The number of total oocytes (18.2 +/- 0.6 versus 20.8 +/- 0.6; P = 0.003) and the number of mature oocytes retrieved (16.9 +/- 0.6 versus 19.4 +/- 0.6; P = 0.005) were different among donors with progesterone < 1.2 ng/ml and PL, respectively. There were no differences between the oocyte recipients in fertilization, cleavage, embryo division on day 3, blastocyst development or fragmentation rates. The number of embryos transferred, number of embryos cryopreserved, and implantation and miscarriage rates were similar between the groups.
PL does not appear to have a negative impact on ongoing PR in our oocyte-donation programme.
多项证据表明，过早黄素化（PL）可能会影响体外受精（IVF）结局。本研究的主要终点是验证PL对我们卵母细胞捐赠计划妊娠率（PR）的影响。
PL定义为人绒毛膜促性腺激素（HCG）当天血清孕酮≥1.2 ng/ml。我们回顾性分析了240个卵母细胞捐赠周期，其中120名女性进行了两次捐赠，第一次捐赠周期存在PL，第二次不存在PL，以此作为自身对照。根据是否存在PL，将受体（n = 240）分为两组（n = 120）。比较两组的供体周期参数和受体周期结局。
两组的PR无差异（分别为55.7%和54.4%）。孕酮<1.2 ng/ml的供体与存在PL的供体相比，总卵母细胞数（分别为18.2±0.6和20.8±0.6；P = 0.003）和回收的成熟卵母细胞数（分别为16.9±0.6和19.4±0.6；P = 0.005）不同。卵母细胞受体在受精、卵裂、第3天胚胎分裂、囊胚发育或碎片率方面无差异。两组之间移植的胚胎数、冷冻保存的胚胎数、着床率和流产率相似。
在我们的卵母细胞捐赠计划中，PL似乎对持续妊娠率没有负面影响。
