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精神分裂症首发及自杀行为的早期检测。

Early detection of the first episode of schizophrenia and suicidal behavior.

作者信息

Melle Ingrid, Johannesen Jan Olav, Friis Svein, Haahr Ulrik, Joa Inge, Larsen Tor K, Opjordsmoen Stein, Rund Bjørn R, Simonsen Erik, Vaglum Per, McGlashan Thomas

机构信息

Department of Research and Education, Division of Psychiatry, Ullevål University Hospital, N-0407 Oslo, Norway.

出版信息

Am J Psychiatry. 2006 May;163(5):800-4. doi: 10.1176/ajp.2006.163.5.800.

Abstract

OBJECTIVE

The suicide rate in schizophrenia is high, with the risk being highest early in the course. The rate of suicide attempts before treatment onset is also high and is often the event leading up to first treatment contact. A previous report showed that the duration of untreated psychosis can be reduced through an early detection program, and that the reduction was associated with lower symptom levels at treatment initiation. Treatment programs that bring first-episode patients into treatment at lower symptom levels can have the potential to reduce risk for suicide attempts.

METHOD

The authors examined consecutive patients with nonorganic, nonaffective psychosis who sought initial treatment at psychiatric treatment units in four catchment areas: two that had an early detection program and two that did not.

RESULTS

The rate of severe suicidality (plans or attempts) was significantly higher in subjects from communities without the early detection program relative to those from early detection communities, even after adjustments for known predictors of suicidality.

CONCLUSION

Early detection programs that bring patients into treatment at lower symptom levels may reduce suicidality risk at first treatment contact.

摘要

目的

精神分裂症的自杀率很高,在病程早期风险最高。治疗开始前的自杀未遂率也很高,且常常是导致首次治疗接触的事件。先前的一份报告显示,通过早期检测项目可以缩短未治疗精神病的持续时间,且这种缩短与治疗开始时较低的症状水平相关。能使首发患者在较低症状水平下接受治疗的项目有可能降低自杀未遂风险。

方法

作者研究了在四个集水区的精神科治疗单位寻求初始治疗的连续性非器质性、非情感性精神病患者:其中两个有早期检测项目,另外两个没有。

结果

即使在对已知的自杀倾向预测因素进行调整之后,来自没有早期检测项目社区的受试者的严重自杀倾向(计划或企图)发生率仍显著高于来自有早期检测项目社区的受试者。

结论

能使患者在较低症状水平下接受治疗的早期检测项目可能会降低首次治疗接触时的自杀倾向风险。

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