视空间能力和注意力是中老年精神分裂症患者自杀意念的危险因素：一项横断面研究。

Visuospatial ability and attention as risk factors for suicidal ideation in middle-aged and elderly schizophrenia patients: a cross-sectional study.

机构信息

School of Mental Health, Wenzhou Medical University, Wenzhou, China.

The Affiliated Kangning Hospital of Wenzhou Medical University Zhejiang Provincial Clinical Research Center for Mental Disorder, Wenzhou, China.

出版信息

BMC Psychiatry. 2023 Oct 18;23(1):765. doi: 10.1186/s12888-023-05272-z.

DOI:10.1186/s12888-023-05272-z

PMID:37853396

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10585849/

Abstract

BACKGROUND

Schizophrenia patients have a high risk of suicide, and their cognition function is impaired with increasing age. The association between neurocognitive and suicidality in schizophrenia patients are heterogeneous. We aimed to explore the relationship between neurocognitive function and suicidal ideation in schizophrenia patients across age groups.

METHODS

A total of 587 patients with schizophrenia were enrolled in this study. The schizophrenia patients were divided into young group (aged 18-44) and middle-aged and elderly group (aged 45-70). The schizophrenia patients were divided into suicidal ideation group and non-suicidal ideation group according to the evaluation results of the Beck Scale for Suicide Ideation. Insomnia symptoms were measured by the Insomnia Severity Index (ISI). Psychotic symptoms were measured by the Positive and Negative Syndrome Scale (PANSS), and cognitive function was measured by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS).

RESULTS

There was a negative correlation between the age and attention scores of RBANS (P = 0.018). The young schizophrenia patients had higher risk of suicidality than middle-aged and elderly schizophrenia patients (P = 0.001). In the logistic regression analysis, the scores of ISI and positive symptoms scores of PANSS were associated with suicidal ideation among young schizophrenia patients (All P < 0.05). Age, BMI, the scores of ISI, general symptoms scores of PANSS, visuospatial scores of RBANS and attention scores of RBANS were associated with suicidal ideation in middle-aged and elderly schizophrenia patients (All P < 0.05).

CONCLUSIONS

High visuospatial scores of RBANS and attention scores of RBANS were risk factors for suicidal ideation in middle-aged and elderly schizophrenia patients.

摘要

背景

精神分裂症患者自杀风险较高，且认知功能随年龄增长而受损。精神分裂症患者的神经认知功能与自杀意念之间的关联存在异质性。我们旨在探讨不同年龄组精神分裂症患者的神经认知功能与自杀意念之间的关系。

方法

本研究共纳入 587 例精神分裂症患者。将精神分裂症患者分为青年组（18-44 岁）和中老年组（45-70 岁）。根据贝克自杀意念量表评估结果，将精神分裂症患者分为有自杀意念组和无自杀意念组。采用失眠严重程度指数（ISI）评估失眠症状。采用阳性和阴性症状量表（PANSS）评估精神病症状，采用重复性成套神经心理状态测验（RBANS）评估认知功能。

结果

RBANS 的注意力评分与年龄呈负相关（P = 0.018）。青年精神分裂症患者的自杀风险高于中老年精神分裂症患者（P = 0.001）。Logistic 回归分析显示，ISI 评分和 PANSS 阳性症状评分与青年精神分裂症患者的自杀意念有关（均 P < 0.05）。年龄、BMI、ISI 评分、PANSS 一般症状评分、RBANS 的视空间评分和 RBANS 的注意力评分与中老年精神分裂症患者的自杀意念有关（均 P < 0.05）。