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乳腺癌转移至视神经酷似视神经鞘膜瘤:病例报告及文献复习

Carcinoma of the breast metastatic to the optic nerve mimicking an optic nerve sheath meningioma: case report and review of the literature.

作者信息

Fox Benjamin, Pacheco Paulette, DeMonte Franco

机构信息

Department of Neurosurgery, Baylor College of Medicine, Houston, Texas, USA.

出版信息

Skull Base. 2005 Nov;15(4):281-7; discussion 287-9. doi: 10.1055/s-2005-921935.

Abstract

Isolated metastatic tumors to the optic nerve are extremely rare. We describe a rare and unusual case of metastatic breast carcinoma to the optic nerve that mimicked an optic nerve sheath meningioma in its presentation due to its indolent symptom progression, initial radiological appearance, and minimal growth on serial imaging. The patient, a 46-year-old woman with a history of stable metastatic breast carcinoma, presented with progressive visual loss in her right eye over a 6-month interval. Magnetic resonance imaging revealed an enhancing lesion in the optic canal with an extension to the right anterior clinoid process and planum sphenoidale and into the right orbital apex, consistent with the presumptive diagnosis of optic nerve sheath meningioma. The tumor was resected and pathologically confirmed to be metastatic carcinoma of the breast. The clinical course, radiological features, surgical approach, and treatment strategies are reviewed.

摘要

孤立性视神经转移瘤极为罕见。我们描述了一例罕见且不寻常的乳腺癌转移至视神经的病例,由于其症状进展缓慢、初始影像学表现以及系列成像显示生长缓慢,其表现酷似视神经鞘脑膜瘤。该患者为一名46岁女性,有稳定的转移性乳腺癌病史,在6个月的时间里右眼视力进行性下降。磁共振成像显示视神经管内有一强化病变,延伸至右侧前床突和蝶骨平台,并进入右侧眶尖,符合视神经鞘脑膜瘤的初步诊断。肿瘤被切除,病理证实为乳腺转移癌。本文回顾了其临床过程、影像学特征、手术方法及治疗策略。

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