Kampf Günter, Wigger-Alberti Walter, Wilhelm Klaus-Peter
Bode Chemie GmbH & Co, Scientific Affairs, Melanchthonstr. 27, DE-22525 Hamburg, Germany.
Acta Derm Venereol. 2006;86(2):140-3. doi: 10.2340/00015555-0045.
Alcohol-based hand rubs are used frequently in healthcare settings, but their tolerance among atopic subjects is unknown. The dermal tolerance to five alcohol-based hand rubs was assessed among atopic and non-atopic subjects in a repetitive occlusive patch test. In total, 54 subjects were analysed. One half of the subjects were atopic (modified Erlanger atopy score > or = 8), the other half were non-atopic. Treatments were controlled with water and 2% sodium dodecyl sulphate (SDS). Treatment sites were assessed by visual inspection (tolerability score 0-4). Skin redness was determined with a chromameter. The overall mean tolerability to all five hand rubs was lower than or identical to the negative control (0.02+/-0.07) and significantly different from the SDS control (0.19+/-0.39). Skin redness was in the same range as for the negative control (0.15+/-0.8) which was significantly lower than the SDS control (1.35+/-1.6). A comparison of the atopic and non-atopic subjects revealed no significant difference. In conclusion, we found that tolerance to the five alcohol-based hand rubs was good among atopic and non-atopic subjects.
含酒精的手部消毒剂在医疗环境中经常使用，但特应性个体对其耐受性尚不清楚。在一项重复性封闭贴片试验中，评估了特应性和非特应性个体对五种含酒精手部消毒剂的皮肤耐受性。总共分析了54名受试者。其中一半受试者为特应性（改良的埃尔朗格特应性评分≥8），另一半为非特应性。用水和2%十二烷基硫酸钠（SDS）作为对照处理。通过目视检查评估处理部位（耐受性评分0 - 4）。用色差仪测定皮肤发红情况。对所有五种手部消毒剂的总体平均耐受性低于或等同于阴性对照（0.02±0.07），且与SDS对照（0.19±0.39）有显著差异。皮肤发红情况与阴性对照处于同一范围（0.15±0.8），显著低于SDS对照（1.35±1.6）。特应性和非特应性受试者的比较未发现显著差异。总之，我们发现特应性和非特应性个体对这五种含酒精手部消毒剂的耐受性良好。
