Kluge Stefan, Kreymann Georg
Medizinische Intensivstation, Klinik für Intensivmedizin, Universitätsklinikum Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg.
Med Klin (Munich). 2006 Mar 15;101(3):203-7. doi: 10.1007/s00063-006-1025-9.
The favorable effect of hypothermia on brain damage resulting from cardiac arrest was first demonstrated in animal studies. Subsequent small-scale human studies have also shown positive effects. In 2002, two large randomized studies investigating the use of controlled mild hypothermia after resuscitation were published in the New England Journal of Medicine. The results convincingly showed a positive effect on survival and neurologic outcome. Based on the currently available data, the International Liaison Committee on Resuscitation (ILCOR) strongly recommends that unconscious adult patients who are resuscitated after ventricular fibrillation be cooled to temperatures between 32 and 34 degrees C for 12-24 h.
低温对心脏骤停所致脑损伤的有益作用首先在动物研究中得到证实。随后的小规模人体研究也显示出积极效果。2002年,两项关于复苏后使用控制性轻度低温的大型随机研究发表在《新英格兰医学杂志》上。结果令人信服地表明其对生存和神经功能结局有积极影响。基于目前可得的数据,国际复苏联合委员会(ILCOR)强烈建议,心室颤动复苏后的成年昏迷患者应将体温降至32至34摄氏度,并维持12 - 24小时。