Abdelrazek Fathy M, Michael Farid A, Mohamed Alaa E
Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt.
Arch Pharm (Weinheim). 2006 Jun;339(6):305-12. doi: 10.1002/ardp.200500259.
2-(5-Chloro-1,3-diphenyl-1H-pyrazol-4-ylmethylene)-malononitrile 1a reacts with the arylidenes of malononitrile 2a-d to afford the triaryl-5-chloropyrazoles 3a-d, respectively. 1a reacts with the active methylene pyrazolinones 5a, b and 12a, b to afford different products 8, 9, 10, 11, and 14a, b--depending on the substitution in the pyrazole ring. Compound 1a reacts also with the pyridazinone derivative 15 to afford the phthalazinone 16, and with the thiazolinones 17a-c to afford the pyrano[2,3-d]thiazoles 20a-c, respectively. It reacts also with the malononitrile dimer 21a and with ethyl cyanoacetate dimer 21b to yield the pyrazolyl pyridines 22a, b, respectively. The synthesized compounds showed a moderate molluscicidal activity towards Biomphalaria alexandrina snails.
2-(5-氯-1,3-二苯基-1H-吡唑-4-基亚甲基)-丙二腈1a与丙二腈2a-d的亚芳基反应，分别得到三芳基-5-氯吡唑3a-d。1a与活性亚甲基吡唑啉酮5a、b和12a、b反应，根据吡唑环上的取代情况得到不同的产物8、9、10、11以及14a、b。化合物1a还与哒嗪酮衍生物15反应得到酞嗪酮16，与噻唑啉酮17a-c反应分别得到吡喃并[2,3-d]噻唑20a-c。它还与丙二腈二聚体21a以及氰基乙酸乙酯二聚体21b反应，分别生成吡唑基吡啶22a、b。合成的化合物对埃及钉螺显示出中等程度的杀螺活性。
