Sasak C
Everest Healthcare Services Corp. Oak Park, Illinois, USA.
Nephrol Nurs J. 2000 Dec;27(6):612-5.
Stimulation of red blood cell precursors by Epoetin alfa results in a predictable, dose-dependent increase in red blood cell mass. Iron is an important substrate that supports red blood cell and hemoglobin development. Patients who receive Epoetin alfa therapy typically require intravenous iron supplementation to ensure proper red cell formation. Target and ceiling iron levels should be determined on the basis of safety considerations, the predicted clinical response, and individual patient replacement needs. Nurses can use clinical parameters such as body weight, baseline and target hemoglobin values, and iron losses from blood and other sources to estimate iron replacement doses, thereby providing a guide for appropriate iron replacement.
促红细胞生成素α对红细胞前体的刺激会导致红细胞量出现可预测的、剂量依赖性增加。铁是支持红细胞和血红蛋白生成的重要底物。接受促红细胞生成素α治疗的患者通常需要静脉补充铁剂，以确保红细胞正常生成。应基于安全性考量、预期临床反应及个体患者的补充需求来确定铁的目标水平和上限。护士可利用体重、基线和目标血红蛋白值以及血液和其他来源的铁流失等临床参数来估算铁补充剂量，从而为适当的铁补充提供指导。
