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1
Aspirin resistance, an emerging, often overlooked, factor in the management of patients with coronary artery disease.阿司匹林抵抗是冠心病患者管理中一个新出现且常被忽视的因素。
Clin Cardiol. 2006 Apr;29(4):144-8. doi: 10.1002/clc.4960290404.
2
Aspirin resistance, an emerging, often overlooked, factor in the management of patients with coronary artery disease.阿司匹林抵抗是冠状动脉疾病患者管理中一个新出现且常被忽视的因素。
Clin Cardiol. 2006 Aug;29(8):334; author reply 334. doi: 10.1002/clc.4960290802.
3
Aspirin and aspirin resistance in coronary artery disease.阿司匹林与冠心病及阿司匹林抵抗
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Antiplatelet effect of aspirin in patients with coronary artery disease.阿司匹林对冠状动脉疾病患者的抗血小板作用。
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Reduced Antiplatelet Effect of Aspirin Does Not Predict Cardiovascular Events in Patients With Stable Coronary Artery Disease.阿司匹林抗血小板作用降低并不能预测稳定型冠状动脉疾病患者的心血管事件。
J Am Heart Assoc. 2017 Aug 5;6(8):e006050. doi: 10.1161/JAHA.117.006050.
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Aspirin and clopidogrel response variability: review of the published literature.阿司匹林和氯吡格雷反应变异性：已发表文献综述
Tex Heart Inst J. 2008;35(3):313-20.
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Relation between atherosclerosis risk factors and aspirin resistance in a primary prevention population.一级预防人群中动脉粥样硬化危险因素与阿司匹林抵抗的关系。
Am J Cardiol. 2006 Sep 15;98(6):774-9. doi: 10.1016/j.amjcard.2006.04.015. Epub 2006 Jul 28.
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The aspirin resistance controversy: clinical entity or platelet heterogeneity?阿司匹林抵抗争议：临床实体还是血小板异质性？
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Homocysteine is a novel risk factor for suboptimal response of blood platelets to acetylsalicylic acid in coronary artery disease: a randomized multicenter study.同型半胱氨酸是冠心病患者血小板对乙酰水杨酸反应不佳的新的危险因素：一项随机多中心研究。
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Aspirin resistance in patients with stable coronary artery disease with and without a history of myocardial infarction.有或无心肌梗死病史的稳定型冠心病患者的阿司匹林抵抗
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引用本文的文献

1
Aspirin resistance, an emerging, often overlooked, factor in the management of patients with coronary artery disease.阿司匹林抵抗是冠状动脉疾病患者管理中一个新出现且常被忽视的因素。
Clin Cardiol. 2006 Aug;29(8):334; author reply 334. doi: 10.1002/clc.4960290802.

本文引用的文献

1
Aspirin resistance is associated with a high incidence of myonecrosis after non-urgent percutaneous coronary intervention despite clopidogrel pretreatment.尽管进行了氯吡格雷预处理，但阿司匹林抵抗与非紧急经皮冠状动脉介入治疗后心肌坏死的高发生率相关。
J Am Coll Cardiol. 2004 Mar 17;43(6):1122-6. doi: 10.1016/j.jacc.2003.12.034.
2
Aspirin resistance: myth or reality?阿司匹林抵抗：神话还是现实？
Indian Heart J. 2003 May-Jun;55(3):217-22.
3
Aspirin resistance: a revival of platelet aggregation tests?
J Thromb Haemost. 2003 Sep;1(9):2048-50. doi: 10.1046/j.1538-7836.2003.00354.x.
4
Aspirin resistance: definition, mechanisms and clinical read-outs.阿司匹林抵抗：定义、机制及临床指标
J Thromb Haemost. 2003 Aug;1(8):1710-3. doi: 10.1046/j.1538-7836.2003.00284.x.
5
Elevated erythrocyte aggregation as a predisposing factor to aspirin resistance.红细胞聚集性升高作为阿司匹林抵抗的一个易感因素。
Thromb Haemost. 2003 Jul;90(1):157.
6
Aspirin and clopidogrel in acute coronary syndromes: therapeutic insights from the CURE study.阿司匹林与氯吡格雷用于急性冠脉综合征：来自CURE研究的治疗见解
Arch Intern Med. 2003 May 26;163(10):1145-53. doi: 10.1001/archinte.163.10.1145.
7
Aspirin resistance: a new independent predictor of vascular events?阿司匹林抵抗：血管事件的一个新的独立预测因素？
J Am Coll Cardiol. 2003 Mar 19;41(6):966-8. doi: 10.1016/s0735-1097(02)03013-9.
8
A prospective, blinded determination of the natural history of aspirin resistance among stable patients with cardiovascular disease.一项针对心血管疾病稳定患者阿司匹林抵抗自然史的前瞻性、盲法研究。
J Am Coll Cardiol. 2003 Mar 19;41(6):961-5. doi: 10.1016/s0735-1097(02)03014-0.
9
Aspirin non-responsiveness as measured by PFA-100 in patients with coronary artery disease.采用血小板功能分析仪（PFA-100）检测冠心病患者的阿司匹林抵抗情况。
Thromb Res. 2002 Oct 1;108(1):37-42. doi: 10.1016/s0049-3848(02)00405-x.
10
Aspirin non-responder status in patients with recurrent cerebral ischemic attacks.复发性脑缺血发作患者的阿司匹林无反应状态
J Neurol. 2003 Jan;250(1):63-6. doi: 10.1007/s00415-003-0954-y.

阿司匹林抵抗是冠心病患者管理中一个新出现且常被忽视的因素。

Aspirin resistance, an emerging, often overlooked, factor in the management of patients with coronary artery disease.

作者信息

Makaryus Amgad N

机构信息

Division of Cardiology, North Shore University Hospital, Manhasset, New York 11030, USA.

出版信息

Clin Cardiol. 2006 Apr;29(4):144-8. doi: 10.1002/clc.4960290404.

DOI:10.1002/clc.4960290404
PMID:16649722
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6654371/
Abstract

Aspirin is the most widely used medication in patients with cardiovascular disease. It has had a greater effect on patients with cardiovascular disease than any other drug. With the importance of aspirin now known for decades, it is recently becoming clearer that some patients do not derive as great a benefit from this "wonder drug" secondary to their resistance to its effects. Aspirin resistance, its prevalence, its identification, and how to overcome or avert it with other medications then becomes a central topic of discussion as important, if not more so, than the importance of aspirin itself as a cornerstone in the treatment of patients with cardiovascular disease. This review explores the current understanding of the mechanism of aspirin resistance with regard to its prevalence and the magnitude of its clinical significance. It also examines the therapeutic implications of a diagnosis of aspirin resistance.

摘要

阿司匹林是心血管疾病患者中使用最广泛的药物。它对心血管疾病患者的影响比任何其他药物都更大。几十年来，阿司匹林的重要性已为人所知，最近越来越清楚的是，一些患者由于对其作用产生抵抗，并未从这种“神奇药物”中获得同样大的益处。阿司匹林抵抗、其患病率、其识别方法，以及如何用其他药物克服或避免它，随之成为一个核心讨论话题，其重要性即便不比阿司匹林本身作为心血管疾病患者治疗基石的重要性更大，至少也是同等重要。这篇综述探讨了目前对阿司匹林抵抗机制的理解，包括其患病率及其临床意义的程度。它还研究了阿司匹林抵抗诊断的治疗意义。