Sakamoto F H, Colleoni G W B, Teixeira S P, Yamamoto M, Michalany N S, Almeida F A, Chiba A K, Petri V, Fernandes M A, Pombo-de-Oliveira M S
Department of Dermatology, Discipline of Hematology and Hemotherapy, Universidade Federal de São Paulo -, Brazil.
Int J Dermatol. 2006 Apr;45(4):447-9. doi: 10.1111/j.1365-4632.2006.02687.x.
Adult T-cell leukemia/lymphoma (ATLL) is a malignant proliferation of mature helper T lymphocytes,(1) and is caused by human T-lymphotropic virus type I (HTLV-I);(2) an HTLV-I infection endemic in the Caribbean, south-western Japan, South America and Africa.(3,4) Seroepidemiological studies suggest that it is also endemic in Brazil.(5) Although carriers of HTLV-I show polyclonal integration of virus in T lymphocytes, only patients with ATLL of various subtypes show monoclonal integration of HTLV-I in tumor cells.(6,7) Cutaneous T-cell lymphomas (CTCL) are a group of primary cutaneous lymphoproliferative diseases(8) with unknown etiology.(9) The two most common presentations of CTCL are mycosis fungoides (MF) and Sézary syndrome (SS).(10-13) However, both CTCL categories can easily resemble ATLL. Therefore, in HTLV-I endemic areas, differentiation between ATLL and CTCL must be performed, as they have different prognoses and treatment approaches.(14).
成人T细胞白血病/淋巴瘤（ATLL）是成熟辅助性T淋巴细胞的恶性增殖，（1）由I型人类嗜T淋巴细胞病毒（HTLV-I）引起；（2）HTLV-I感染在加勒比地区、日本西南部、南美洲和非洲呈地方性流行。（3,4）血清流行病学研究表明，巴西也存在地方性流行。（5）虽然HTLV-I携带者的T淋巴细胞中病毒呈多克隆整合，但只有各种亚型的ATLL患者的肿瘤细胞中HTLV-I呈单克隆整合。（6,7）皮肤T细胞淋巴瘤（CTCL）是一组病因不明的原发性皮肤淋巴增殖性疾病（8）。（9）CTCL最常见的两种表现形式是蕈样肉芽肿（MF）和塞扎里综合征（SS）。（10 - 13）然而，这两种CTCL类型都很容易与ATLL相似。因此，在HTLV-I地方性流行地区，必须对ATLL和CTCL进行鉴别，因为它们的预后和治疗方法不同。（14）
