Lewis A B, Sadeghi M
Division of Cardiology, Childrens Hospital of Los Angeles, Calif.
Biol Neonate. 1991;60(5):327-32. doi: 10.1159/000243425.
The interaction between the plasma catecholamine response to hypoxemia and endogenous opiate receptor blockade was investigated in 9 fetal lambs. The animals were randomly assigned to receive either normal saline (control group 1) or two doses of naloxone (group 2 = 0.5 mg/kg; group 3 = 1.0 mg/kg) by bolus injection followed by continuous infusion. Arterial PO2 decreased from 21 to 12 Torr and remained less than 14 Torr for 1 h. Arterial pH declined from 7.40 to a nadir of 7.32 at 1 h. Mean plasma catecholamine concentrations rose promptly from a baseline of 524-546 pg/ml for norepinephrine (NE) and 156-235 pg/ml for epinephrine (E) to reach a peak at 15 min (NE = 2,476-3,276, p less than 0.01; E = 1,856-4,065 pg/ml, p less than 0.01) and remained elevated thereafter. Neither dose of naloxone significantly altered plasma NE or E concentrations. Therefore, we conclude that endogenous opiates do not modulate the sympathoadrenal response to moderately long periods of hypoxemia unaccompanied by acidemia.
在9只胎羊中研究了低氧血症时血浆儿茶酚胺反应与内源性阿片受体阻断之间的相互作用。将动物随机分为两组，一组接受生理盐水（对照组1），另一组通过推注然后持续输注接受两剂纳洛酮（第2组=0.5mg/kg；第3组=1.0mg/kg）。动脉血氧分压从21 Torr降至12 Torr，并在1小时内维持在14 Torr以下。动脉血pH值从7.40降至1小时时的最低点7.32。血浆去甲肾上腺素（NE）的平均浓度从基线的524 - 546 pg/ml迅速上升，肾上腺素（E）从156 - 235 pg/ml迅速上升，在15分钟时达到峰值（NE = 2476 - 3276，p<0.01；E = 1856 - 4065 pg/ml，p<0.01），此后一直保持升高。两种剂量的纳洛酮均未显著改变血浆NE或E的浓度。因此，我们得出结论，内源性阿片类物质不会调节在无酸血症的情况下对中度长时间低氧血症的交感肾上腺反应。
