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甘油磷脂乙醇胺三肽类似物的神经保护活性与谷氨酸受体结合亲和力无关。

The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity.

作者信息

Alonso De Diego Sergio A, Gutiérrez-Rodríguez Marta, Pérez de Vega M Jesús, González-Muñiz Rosario, Herranz Rosario, Martín-Martínez Mercedes, Cenarruzabeitia Edurne, Frechilla Diana, Del Río Joaquín, Jimeno M Luisa, García-López M Teresa

机构信息

Instituto de Química Médica Juan de la Cierva, 3, 28006 Madrid, Spain.

出版信息

Bioorg Med Chem Lett. 2006 Jul 1;16(13):3396-400. doi: 10.1016/j.bmcl.2006.04.033. Epub 2006 May 2.

DOI:10.1016/j.bmcl.2006.04.033
PMID:16650992
Abstract

The influence of several modifications on the GPE tripeptide structure upon the binding to GluRs and on their neuroprotective effects has been studied. The results indicated that the prevention of neuronal death showed by GPE and some analogues is not directly related to their affinity at glutamate receptors.

摘要

已经研究了几种修饰对GPE三肽结构与谷氨酸受体结合的影响及其神经保护作用。结果表明，GPE和一些类似物所表现出的对神经元死亡的预防作用与其对谷氨酸受体的亲和力没有直接关系。

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