Yang Jing, Mani Sendurai A, Weinberg Robert A
Whitehead Institute for Biomedical Research, Cambridge Center, Cambridge, Massachusetts 02142, USA.
Cancer Res. 2006 May 1;66(9):4549-52. doi: 10.1158/0008-5472.CAN-05-3850.
Unraveling the genetic programs that drive -metastasis may offer insights into how to limit or prevent this deadly aspect of cancer progression. Our recent studies indicate that tumor cell metastasis involves the activity of the transcription factor, Twist, which regulates epithelial-mesenchymal transition and early embryonic morphogenesis. Here, we review the Twist signaling pathway during normal development and discuss how the transcription factor Twist and the epithelial-mesenchymal transition program impinge their biological functions during tumor metastasis.
揭示驱动转移的基因程序可能为限制或预防癌症进展这一致命方面提供见解。我们最近的研究表明，肿瘤细胞转移涉及转录因子Twist的活性，该因子调节上皮-间质转化和早期胚胎形态发生。在此，我们回顾正常发育过程中的Twist信号通路，并讨论转录因子Twist和上皮-间质转化程序在肿瘤转移过程中如何发挥其生物学功能。
