关于使用预试验来指导研究方案的功效计算的注意事项。

Caution regarding the use of pilot studies to guide power calculations for study proposals.

作者信息

Kraemer Helena Chmura, Mintz Jim, Noda Art, Tinklenberg Jared, Yesavage Jerome A

机构信息

Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif 94305, USA.

出版信息

Arch Gen Psychiatry. 2006 May;63(5):484-9. doi: 10.1001/archpsyc.63.5.484.

DOI:10.1001/archpsyc.63.5.484

PMID:16651505

Abstract

Clinical researchers often propose (or review committees demand) pilot studies to determine whether a study is worth performing and to guide power calculations. The most likely outcomes are that (1) studies worth performing are aborted and (2) studies that are not aborted are underpowered. There are many excellent reasons for performing pilot studies. The argument herein is not meant to discourage clinical researchers from performing pilot studies (or review committees from requiring them) but simply to caution against their use for the objective of guiding power calculations.

摘要

临床研究人员经常提议（或审查委员会要求）开展试点研究，以确定一项研究是否值得进行，并指导样本量计算。最可能出现的结果是：（1）值得进行的研究被中止；（2）未被中止的研究样本量不足。开展试点研究有许多充分的理由。本文的观点并非意在劝阻临床研究人员开展试点研究（或审查委员会要求开展试点研究），而只是提醒不要将其用于指导样本量计算这一目的。