Kovács T, Csákány B, Török A, Csillik B
Department of Anatomy, Albert Szent-Györgyi Medical University, Szeged, Hungary.
J Hirnforsch. 1991;32(2):195-201.
Systemic lanthanum chloride administration results in impeded myelin formation of regenerating peripheral axons and in marked decrease of regenerative elongation of dorsal root axons within the upper dorsal horn of the spinal cord. It is assumed that the inhibitory action of lanthanum ions is based on a competitive antagonism with calcium ions, insofar as lanthanum ions induce blockade of calcium channels in axonal growth cones. Consequently, motility: of axonal filopodia emanating from axonal growth cones, instrumental in longitudinal growth of regenerating central axons, is inhibited by lanthanum ions. Supposedly, a similar inhibitory action upon rotational movement of Schwann cells results in the retarded myelinization of peripheral axons.
全身性给予氯化镧会导致再生外周轴突的髓鞘形成受阻，以及脊髓上背角内背根轴突的再生伸长显著减少。据推测，镧离子的抑制作用基于与钙离子的竞争性拮抗作用，因为镧离子会诱导轴突生长锥中钙通道的阻断。因此，从轴突生长锥发出的轴突丝状伪足的运动性（这对再生中枢轴突的纵向生长至关重要）会受到镧离子的抑制。据推测，对施万细胞旋转运动的类似抑制作用会导致外周轴突的髓鞘化延迟。
