来自不良恩氏木的生物活性新木脂素。

Bioactive neolignans from Endlicheria dysodantha.

作者信息

Ma W W, Kozlowski J F, McLaughlin J L

机构信息

Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907.

出版信息

J Nat Prod. 1991 Jul-Aug;54(4):1153-8. doi: 10.1021/np50076a045.

DOI:10.1021/np50076a045

PMID:1665173

Abstract

From bioactivity-directed fractionation of the EtOH extract of Endlicheria dysodantha, dysodanthin A and dysodanthin B, which are new hexahydrobenzofuranoid neolignans, have been isolated. In addition, the known neolignans, compound 4, which is a burchellin analogue, and megaphone acetate [1] were isolated. All four neolignans showed activities in the brine shrimp lethality test; compounds 1-3 also inhibited the growth of crown gall tumors on potato discs and were cytotoxic to human tumor cells in culture. This is the first report of these neolignans isolated from the genus Endlicheria and of their completely assigned 1H-and 13C-nmr data.

摘要

通过对 dysodantha 黄肉楠（Endlicheria dysodantha）乙醇提取物进行生物活性导向的分级分离，得到了新的六氢苯并呋喃类新木脂素 dysodanthin A 和 dysodanthin B。此外，还分离出了已知的新木脂素，即与 burchellin 类似的化合物 4 和乙酸大喇叭茶素[1]。所有这四种新木脂素在卤虫致死试验中均表现出活性；化合物 1 - 3 还抑制了马铃薯圆盘上冠瘿瘤的生长，并且对培养中的人肿瘤细胞具有细胞毒性。这是首次从黄肉楠属植物中分离出这些新木脂素并报道其完整的 1H 和 13C - NMR 数据。