木香的细胞毒性成分。

Cytotoxic constituents of Saussurea lappa.

作者信息

Jung J H, Kim Y, Lee C O, Kang S S, Park J H, Im K S

机构信息

College of Pharmacy, Pusan National University, Korea.

出版信息

Arch Pharm Res. 1998 Apr;21(2):153-6. doi: 10.1007/BF02974020.

DOI:10.1007/BF02974020

PMID:9875423

Abstract

The crude extract of Saussurea lappa displayed significant lethality to brine shrimp larvae. Investigation of the causative components by bioactivity-directed fractionation resulted in the isolation of three C17-polyene alcohols. Based on various nmr spectral data, these compounds were identified as shikokiols which had been previously isolated from Cirsium nipponicum and/or Centaurea aegyptica. These C17-polyene alcohols exhibited moderate cytotoxicities against the human tumor cell lines, A549, SK-OV-3, SK-MEL-2, XF498, and HCT15.

摘要

木香粗提物对卤虫幼虫显示出显著的致死性。通过生物活性导向分级分离对致病成分进行研究，结果分离出三种C17 - 多烯醇。基于各种核磁共振光谱数据，这些化合物被鉴定为紫铆醇，此前已从日本蓟和/或埃及矢车菊中分离得到。这些C17 - 多烯醇对人肿瘤细胞系A549、SK - OV - 3、SK - MEL - 2、XF498和HCT15表现出中等程度的细胞毒性。