Laphookhieo Surat, Syers John Keith, Kiattansakul Rattana, Chantrapromma Kan
School of Science, Mae Fah Luang University, Thasud, Muang, Chiang Rai 57100, Thailand.
Chem Pharm Bull (Tokyo). 2006 May;54(5):745-7. doi: 10.1248/cpb.54.745.
A new prenylated xanthone, 5-O-methylcelebixanthone (1), together with six known compounds; celebixanthone (2), 1,3,7-trihydroxy-2,4-di(3-methylbut-2-enyl)xanthone (3), cochinchinone A (4), alpha-mangostin (5), beta-mangostin (6) and cochinchinone C (7) were isolated from roots of Cratoxylum cochinchinense. Their structures were elucidated by spectroscopic methods. Compounds 2 and 4-7 showed cytotoxic activity against the human lung cancer cell line (NCI-H187) with IC(50) values ranging from 0.65 to 5.2 microg/ml. Compounds 1, 2, 6 and 7 also showed antimalarial activity against Plasmodium falciparum with IC(50) values of 3.2, 4.9, 7.2 and 2.6 microg/ml, respectively.
从黄牛木的根部分离出一种新的异戊烯基呫吨酮，5-O-甲基黄牛木呫吨酮（1），以及六种已知化合物；黄牛木呫吨酮（2）、1,3,7-三羟基-2,4-二（3-甲基丁-2-烯基）呫吨酮（3）、柯因钦酮A（4）、α-山竹黄酮（5）、β-山竹黄酮（6）和柯因钦酮C（7）。通过光谱方法阐明了它们的结构。化合物2和4-7对人肺癌细胞系（NCI-H187）显示出细胞毒性活性，IC50值范围为0.65至5.2微克/毫升。化合物1、2、6和7对恶性疟原虫也显示出抗疟活性，IC50值分别为3.2、4.9、7.2和2.6微克/毫升。
