Klein M Ines, Coviello Silvina, Bauer Gabriela, Benitez Alicia, Serra M Elina, Schiatti M Paula, Delgado M Florencia, Melendi Guillermina A, Novalli Luis, Pena Hebe Gonzalez, Karron Ruth A, Kleeberger Steven R, Polack Fernando P
Fundacion INFANT, Buenos Aires, Argentina.
J Infect Dis. 2006 Jun 1;193(11):1544-51. doi: 10.1086/503806. Epub 2006 Apr 27.
We conducted a prospective, observational study to characterize the clinical manifestations of respiratory infections caused by human metapneumovirus (hMPV) and other viruses in 194 premature infants and young children with chronic lung disease or congenital heart disease in Buenos Aires. Children had 567 episodes of respiratory illness and were monitored until they were 2 years old or until the completion of the study. hMPV elicited 12 infections (2%) year-round; 30% were of moderate or greater severity. Human parainfluenza virus type 3 caused 24 infections (4%), and 5 (25%) of 20 lung infections led to hospitalization. Respiratory syncytial virus (RSV) caused 33 episodes--17% of infections and 32% of hospitalizations during the respiratory season. None of the 10 children infected with influenza virus had severe disease. The present study of at-risk children suggests that hMPV and influenza virus are infrequent agents of severe disease and highlights the need for preventive interventions against RSV in developing countries.
我们进行了一项前瞻性观察性研究，以描述布宜诺斯艾利斯194名患有慢性肺病或先天性心脏病的早产和幼儿中，人偏肺病毒（hMPV）及其他病毒引起的呼吸道感染的临床表现。这些儿童出现了567次呼吸道疾病发作，并被监测至2岁或直至研究结束。hMPV全年引发了12次感染（2%）；其中30%为中度或更严重感染。3型人副流感病毒引发了24次感染（4%），20次肺部感染中有5次（25%）导致住院。呼吸道合胞病毒（RSV）引发了33次发作——占呼吸道疾病季节感染的17%和住院的32%。10名感染流感病毒的儿童均未患严重疾病。这项针对高危儿童的研究表明，hMPV和流感病毒是导致严重疾病的罕见病原体，并凸显了发展中国家针对RSV进行预防干预的必要性。
