[维拉帕米和地尔硫䓬对阿曲库铵体内肌肉松弛作用的影响]

[Influence of verapamil and diltiazem on the muscle-relaxing effect of atracurium in vivo].

作者信息

Gómez Iglesias E, García Pascual E, Aguirre Gómez C, Rodríguez-Sasiaín J M, Calvo Duo R

机构信息

Departamento de Farmacología, Hospital de Galdakao.

出版信息

Rev Esp Anestesiol Reanim. 1991 Sep-Oct;38(5):297-300.

PMID:1665242

Abstract

The interaction between atracurium and the two calcium antagonists verapamil and diltiazem were studied in rabbits. It was observed that intravenous verapamil (0.2 mg/kg) reduced by 25% and 30% respectively, the dose of atracurium required to produce a 50% or 95% of neuromuscular blockade. In contrast, intravenous diltiazem (1 mg/kg) failed to produce significant changes.

摘要

在兔身上研究了阿曲库铵与两种钙拮抗剂维拉帕米和地尔硫䓬之间的相互作用。观察到静脉注射维拉帕米（0.2mg/kg）分别使产生50%或95%神经肌肉阻滞所需的阿曲库铵剂量降低了25%和30%。相比之下，静脉注射地尔硫䓬（1mg/kg）未产生显著变化。