Rohner-Jeanrenaud F, Jeanrenaud B
Laboratoires de Recherches Métaboliques, Faculty and Department of Medicine, Geneva, Switzerland.
Int J Obes. 1991 Sep;15 Suppl 2:117-22.
Perturbances in the autonomic nervous control of different target tissues (e.g. endocrine pancreas, brown adipose tissue) are present in the genetically obese (fa/fa) rat. These disorders are probably secondary to central dysregulation(s). In view of the reported effects of CRF in stimulating sympathetic nerve-mediated mechanisms while inhibiting vagus nerve-mediated ones, ovine CRF (oCRF) was administered for 7 days into the cerebral ventricles of fa/fa rats. oCRF treatment stopped the excessive weight gain of the obese animals. The oCRF effect was unrelated to changes in food intake, as the two groups were pair-fed. oCRF-treated obese rats were characterized by a decrease in basal hyperinsulinemia, increases in brown adipose tissue weight and activity, and decreases in hepatic glycogen content and epididymal fat pad weight. It is suggested that intracerebroventricular oCRF administration to obese fa/fa rats prevents the increase in body weight observed in vehicle-infused obese rats by modulating the impaired autonomic nervous control of different target tissues. This does not occur in lean rats.
遗传性肥胖（fa/fa）大鼠存在不同靶组织（如内分泌胰腺、棕色脂肪组织）自主神经控制的紊乱。这些紊乱可能继发于中枢调节异常。鉴于促肾上腺皮质激素释放因子（CRF）在刺激交感神经介导机制的同时抑制迷走神经介导机制的报道，将绵羊CRF（oCRF）注入fa/fa大鼠脑室7天。oCRF治疗阻止了肥胖动物的过度体重增加。由于两组采用配对喂食，oCRF的作用与食物摄入量的变化无关。接受oCRF治疗的肥胖大鼠的特征是基础高胰岛素血症降低、棕色脂肪组织重量和活性增加、肝糖原含量和附睾脂肪垫重量降低。提示向肥胖的fa/fa大鼠脑室内注射oCRF可通过调节不同靶组织受损的自主神经控制来防止在注射赋形剂的肥胖大鼠中观察到的体重增加。瘦大鼠不会出现这种情况。
