Anderson H, Prendiville J, Thatcher N, Radford J A, Swindell R
CRC Department of Medical Oncology, Christie Hospital, Manchester, UK.
J Cancer Res Clin Oncol. 1991;117 Suppl 4(Suppl 4):S139-40. doi: 10.1007/BF01613219.
159 "poor risk" patients with previously untreated small cell lung cancer were entered into a randomised study of intravenous bolus versus continuous infusion chemotherapy with doxorubicin on weeks 1, 3, 5 and ifosfamide with mesna on weeks 2, 4, 6. Oral etoposide was given on days 1-5, 15-19, and 29-33. There was no difference in response rate or survival. However, patients treated with continuous infusion therapy had significantly less haematological toxicity (P = 0.0007), and less nausea and vomiting (P = 0.03).
159例既往未接受过治疗的小细胞肺癌“高危”患者进入一项随机研究，比较第1、3、5周静脉推注多柔比星与持续输注多柔比星，以及第2、4、6周异环磷酰胺与美司钠持续输注化疗的效果。第1 - 5天、15 - 19天和29 - 33天给予口服依托泊苷。缓解率或生存率无差异。然而，接受持续输注治疗的患者血液学毒性明显较小（P = 0.0007），恶心和呕吐也较少（P = 0.03）。
