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Localization of mitochondrial DNA in normal and pathological muscle using immunological probes: a new approach to the study of mitochondrial myopathies.

作者信息

Andreetta F, Tritschler H J, Schon E A, DiMauro S, Bonilla E

机构信息

Department of Neurology, College of Physicians and Surgeons of Columbia University, New York, NY 10032.

出版信息

J Neurol Sci. 1991 Sep;105(1):88-92. doi: 10.1016/0022-510x(91)90123-o.

DOI:10.1016/0022-510x(91)90123-o
PMID:1665507
Abstract

We have studied the usefulness of anti-DNA antibodies to detect ragged-red fibers (RRF) in muscle biopsies from patients with mitochondrial myopathies. We have found that these antibodies are excellent probes for the localization of mitochondrial DNA (mtDNA) in RRF, and for the diagnosis of depletion of mtDNA in a newly described group of fatal myopathies of infancy.

摘要

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Localization of mitochondrial DNA in normal and pathological muscle using immunological probes: a new approach to the study of mitochondrial myopathies.
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引用本文的文献

1
Variation in mitochondrial DNA levels in muscle from normal controls. Is depletion of mtDNA in patients with mitochondrial myopathy a distinct clinical syndrome.正常对照者肌肉中线粒体DNA水平的变化。线粒体肌病患者的线粒体DNA耗竭是否为一种独特的临床综合征。
J Inherit Metab Dis. 1995;18(1):4-20. doi: 10.1007/BF00711367.