Andreetta F, Tritschler H J, Schon E A, DiMauro S, Bonilla E
Department of Neurology, College of Physicians and Surgeons of Columbia University, New York, NY 10032.
J Neurol Sci. 1991 Sep;105(1):88-92. doi: 10.1016/0022-510x(91)90123-o.
We have studied the usefulness of anti-DNA antibodies to detect ragged-red fibers (RRF) in muscle biopsies from patients with mitochondrial myopathies. We have found that these antibodies are excellent probes for the localization of mitochondrial DNA (mtDNA) in RRF, and for the diagnosis of depletion of mtDNA in a newly described group of fatal myopathies of infancy.
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